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Testing independence between two sequential gap times in the presence of covariates

✍ Scribed by Pénichoux, Juliette; Moreau, Thierry; Meyer, Laurence; Boufassa, Faroudy; Huber, Catherine; Latouche, Aurélien


Book ID
118753354
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
657 KB
Volume
54
Category
Article
ISSN
0323-3847

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✍ Philippe Broët; Thierry Moreau; Joseph Lellouch; Bernard Asselain 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 2 views

In analysing a clinical trial with the logrank test, the hazards between the two groups are usually assumed to be proportional. Nevertheless, this hypothesis is no longer valid with unobserved covariates. As a consequence, there is a loss of power of the logrank test for testing the null hypothesis