✦ LIBER ✦

Testing human blood for cannabis by GC–MS

✍ Scribed by Pascal Kintz; Vincent Cirimele

Book ID: 101275530
Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 97 KB
Volume: 11
Category: Article
ISSN: 0269-3879
DOI: 10.1002/(sici)1099-0801(199711)11:6<371::aid-bmc685>3.0.co;2-y

No coin nor oath required. For personal study only.

✦ Synopsis

A method for cannabis testing in human whole blood is presented. The procedure involves extraction of a 2 mL specimen acidified with 0.2 mL of 10% acetic acid in a silanized vial in presence of deuterated internal standards into hexane:ethyl acetate. After evaporation to dryness the drug and its metabolite were derivatized by methylation with iodomethane in tetrabutylammonium hydroxide-dimethyl sulphoxide (DMSO). The derivatives were extracted into isoocatane for analysis by gas chromatography-mass spectrometry (GC-MS). The limit of quantification was 1.0 and 0.5 ng/mL for ⌬9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-⌬9-tetrahydrocannabinol (THC-COOH), respectively.

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