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Testing a Primary and a Secondary Endpoint in a Group Sequential Design

✍ Scribed by Ajit C. Tamhane; Cyrus R. Mehta; Lingyun Liu

Book ID: 109224341
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 292 KB
Volume: 66
Category: Article
ISSN: 0006-341X
DOI: 10.1111/j.1541-0420.2010.01402.x

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## Abstract In their review of challenges to multiple testing in clinical trials, Hung and Wang (2010) considered the situation where a treatment is to be compared with an active comparator and the aim is to show non‐inferiority and (if possible) superiority with respect to a primary and a secondar