Testicular tumors with peutz-jeghers syndrome
β Scribed by Darrell M. Wilson; William C. Pitts; Raymond L. Hintz; Ron G. Rosenfeld
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 369 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0008-543X
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The diagnosis of Peutz-Jeghers syndrome is based on the occurrence of hamartomatous gastrointestinal polyps and perioral pigment spots. In view of the development of hamartomatous polyps in several syndromes and the variability of pigment spots in Peutz-Jeghers patients, identification of affected i
Patients with Peutz-Jeghers' syndrome (PJS) develop hamartomatous gastrointestinal polyps and characteristic pigmentation, as a result of germline mutations in the LKB1 gene. The hamartomas in PJS were long considered to be without malignant potential. There is, however, accumulating epidemiological