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Test for qualitative interaction of clinical significance

โœ Scribed by Guohua Pan; Douglas A. Wolfe

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
151 KB
Volume
16
Category
Article
ISSN
0277-6715

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โœฆ Synopsis

We generalize the problem of detecting qualitative interaction between treatments and subsets in a two treatment clinical trial to the more practical problem of detecting a qualitative interaction greater than a non-negative value d, corresponding to the minimal treatment difference of clinical significance. We develop a test based on simultaneous confidence intervals for the generalized problem under the assumption of normality. The proposed test is easy to implement, either by hand calculation or through the use of virtually any existing statistical software. We derive explicit power function for the proposed test and give examples to illustrate the procedures.

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Two methods of setting confidence intervals for test scores and testing the significance of test score differences are compared with respect to their simplicity and the similarity of their results. The conventional method, which is based on obtained scores, is unquestionably simpler than the technic