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Tertiary Interactions between the Fifth and Sixth Transmembrane Segments of Rhodopsin †

✍ Scribed by Struthers, Mary; Yu, Hongbo; Kono, Masahiro; Oprian, Daniel D.

Book ID
127085157
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
96 KB
Volume
38
Category
Article
ISSN
0006-2960

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## Abstract Activation of G protein–coupled receptors (GPCRs) originates in ligand‐induced protein conformational changes that are transmitted to the cytosolic receptor surface. In the photoreceptor rhodopsin, and possibly other rhodopsin‐like GPCRs, protonation of a carboxylic acid in the conserve