tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
✍ Scribed by Chen, Shuang-Wei ;Xu, Cai-Hong ;Zheng, Guo-Rong ;Jin, Xu-Hu
- Book ID
- 104486685
- Publisher
- International Union of Crystallography
- Year
- 2006
- Tongue
- English
- Weight
- 134 KB
- Volume
- 62
- Category
- Article
- ISSN
- 1600-5368
No coin nor oath required. For personal study only.
✦ Synopsis
The title compound, C~12~H~21~NO~3~, is an important intermediate for new dopamine transporter inhibitors. The six-membered ring of the azabicyclo[3.2.1]octane system adopts a chair conformation with the hydroxyl group axial. The fused five-membered ring is in an envelope conformation.
📜 SIMILAR VOLUMES
New methodology for the synthesis of enantiopure 3-aza-6,8-dioxa-bicyclo[3.2.1]octane-carboxylic acids belonging to 7-endo-BTAa sub-class of g/d amino acids is described. The novelty is the use of 2,3-O-isopropylidene-erythrose instead of meso-tartaric acid derivative, thus allowing us to perform an