tert-Butanesulfinylphosphines: Simple Chiral Ligands in Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Electron-Deficient Olefins

✍ Scribed by Feng Lang; Dong Li; Junmin Chen; Jun Chen; Liangchun Li; Linfeng Cun; Jin Zhu; Jingen Deng; Jian Liao

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 191 KB
• Volume: 352
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.200900792

✦ Synopsis

Abstract

An efficient rhodium complex catalyst system was developed by using a class of simple tert‐butanesulfinylphosphines as bidentate ligands, which solely bear sulfur chirality and combine the advantages of both sulfoxide and phosphine ligands. Excellent activities (in 0.5 hour, up to 99% yield) and enantioselectivities (up to 98% ee) were displayed in Rh‐catalyzed asymmetric 1,4‐additions under mild conditions.