Terminalia arjuna: an Ayurvedic Cardiotonic, Regulates Lipid Metabolism in Hyperlipaemic Rats
✍ Scribed by A. K. Khanna; Ramesh Chander; N. K. Kapoor
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 334 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
No coin nor oath required. For personal study only.
✦ Synopsis
The lipid lowering action of the bark powder of Tenninalia arjuna (I: arjuna) has been studied in triton and cholesterol fed rats. Serum lipids were found to be lowered by I: arjuna (100mg/kg, b.w.) in triton induced hyperlipaemia. Chronic feeding of this powder (100mg/kg, b.w., p.0.) in animals simultaneously fed with cholesterol (25 mgkg, b.w.1 for 30 days, caused lowering in lipids and protein levels of plipoproteins followed by an increase in high density lipoprotein-cholesterol compared with the cholesterol fed groups. I: arjuna alters lipolytic activities in plasma, liver, heart and adipose tissues of hyperlipaemic rats. The lipid lowering action of this natural product is mediated through inhibition of hepatic cholesterol biosynthesis, increased faecal bile acid excretion and enhanced plasma 1ecithin:cholesterol acyltransferase activity and stimulation of receptor mediated catabolism of low density lipoprotein.