Terbinafine HCl in a novel alcohol vehicle permeates the human nail and achieves therapeutic concentrations in the nail plate and nail bed

In Vitro penetration of a novel oxaborol

In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate

✍ Xiaoying Hui; Stephen J. Baker; Ronald C. Wester; Sherry Barbadillo; Anne K. Cas 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB

Onychomycosis is a challenging fungal infection to treat topically, likely due to the unique properties of the nail plate. This seemingly impenetrable barrier has high resistance to the passage of antifungal drugs in sufficient concentrations to kill the causative fungi deep in the nail bed. Recentl