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Teratogenicity of 3-deoxyglucosone and diabetic embryopathy

✍ Scribed by Eriksson, U. J.; Wentzel, P.; Minhas, H. S.; Thornalley, P. J.

Book ID
125441731
Publisher
American Diabetes Association
Year
1998
Tongue
English
Weight
326 KB
Volume
47
Category
Article
ISSN
0012-1797

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3-deoxyglucosone (3-DG) is accumulated not only in uremic serum but also in uremic erythrocytes. 3-DG rapidly reacts with protein amino groups to form advanced glycation end products (AGEs) such as imidazolone, pyrraline, and N(epsilon)-(carboxymethyl)lysine, among which imidazolone is the AGE that