The pharmacokinetics of three 13-cis-retinoic acid formulations were studied after intraperitoneal (ip) administration to rats. Rats were given ip injections of 2.5 mg of 13-cis-retinoic acid per 360 g of body weight; the drug was administered as an alkaline solution, suspended in corn oil, or as a
Teratogenicity and Transplacental Pharmacokinetics of 13-cis-Retinoic Acid in Rabbits
โ Scribed by C. Eckhoff; S. Chari; M. Kromka; H. Staudner; L. Juhasz; H. Rudiger; N. Agnish
- Book ID
- 112265650
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 749 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0041-008X
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Pharmacokinetic studies of 13-cis retinoic acid (13cRA) and all-trans retinoic acid (ATRA), the 2 most commonly used retinoids, have suggested significant differences in the disposition of these compounds despite their structural similarity. In vivo treatment with 13cRA has been associated with 20-3
A method employing trifluoroacetic acid for the quantitative determination ofallrrans-retinoic acid and 13-cis-retinoic acid in serum is described. The method permits the detection of as little as 0.3 Kg of either compound. Retinoic acid can serve the general tissue functions of vitamin A, except i