Teratogenic antibody internalization by rat visceral yolk-sac endoderm in vitro: An ultrastructural colloidal gold tracer study
✍ Scribed by Leung, Christopher C. K. ;Yan, Cai-Lou ;Cheewatrakoolpong, Boonlert
- Book ID
- 102698162
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1988
- Tongue
- English
- Weight
- 810 KB
- Volume
- 183
- Category
- Article
- ISSN
- 0002-9106
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✦ Synopsis
Previous work from our laboratory has demonstrated that specific rabbit immunoglobulins G (IgG) against a glycoprotein antigen of rat kidney proximal tubule or a cross-reacting visceral yolk-sac endodermal cell antigen will induce abnormal embryonic development when they are injected into pregnant rats during the period of organogenesis. It has been proposed that these antibodies may induce embryopathy by interfering with functions of the visceral yolksac placenta, an important organ providing nutrients to the embryo at this stage of development. In order to gain some insight into the underlying pathogenic mechanism(s) in which specific teratogenic I& may interfere with visceral yolk-sac functions, we examined the uptake of these teratogenic IgG by the visceral yolk-sac endodermal cells at the electron microscopic level. microscopic level.
It is postulated that the responsible antigen may be a receptor which plays an important role in transporting nutrient($ to the embryo. Specific polyclonal terato-genic IgGs may either interfere with receptor-ligand interaction or inhibit recycling of such a receptor, thereby causing abnormal embryonic development.