✦ LIBER ✦

Teratogen update: Maternal myasthenia gravis as a cause of congenital arthrogryposis

✍ Scribed by Polizzi, A. ;Huson, S.M. ;Vincent, A.

Book ID: 101322803
Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 186 KB
Volume: 62
Category: Article
ISSN: 0040-3709
DOI: 10.1002/1096-9926(200011)62:5<332::aid-tera7>3.0.co;2-e

No coin nor oath required. For personal study only.

✦ Synopsis

Background: Arthrogryposis multiplex congenita (AMC) is defined as nonprogressive congenital contractures that generally result from lack of fetal movement in utero. AMC is a feature of many congenital disorders caused by genetic, environmental, or other factors. One rare cause of AMC is maternal myasthenia gravis (MG). This is an autoimmune disorder, caused by antibodies to the nicotinic acetylcholine receptor (AChR), and resulting in weakness of voluntary muscles. In 10 -15% of babies born to MG mothers, transient signs of MG are noted after placental transfer of anti-AChR antibodies. In a few cases, AMC predominates.

Methods:

We review the role of antibodies to AChR in MG and in AMC associated with maternal antibodies to AChR.

📜 SIMILAR VOLUMES

Asymptomatic maternal myasthenia as a ca

Asymptomatic maternal myasthenia as a cause of the Pena-Shokeir phenotype

✍ Brueton, Louise A.; Huson, Susan M.; Cox, Phillip M.; Shirley, I.; Thompson, Eli 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 33 KB

We report six sibs with arthrogryposis multiplex congenita and a Pena-Shokeir phenotype, born to a healthy woman who was discovered to have asymptomatic myasthenia gravis (MG). This is the first report of anti-acetylcholine receptor (AChR) antibodies causing fetal akinesia/hypokinesia sequence in th

High fever–related maternal diseases as

✍ Andrew E. Czeizel; Erzsébet H. Puhó; Nándor Ács; Ferenc Bánhidy 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 94 KB 👁 2 views

## Abstract ## BACKGROUND: Multiple congenital abnormalities (MCAs) represent the most severe category of structural birth defects; therefore, we decided to evaluate the possible etiological factors for MCAs. ## METHODS: The population‐based large data set of the Hungarian Case‐Control Surveilla