Terahertz spectroscopy to identify the polymorphs in freeze-dried mannitol
✍ Scribed by Reshmi Chakkittakandy; Jos A.W.M. Corver; Paul C.M. Planken
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 312 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
We show how terahertz time-domain spectroscopy (THz-TDS) in the range from 0.1 to 7.5 THz can be used to identify the polymorphs of Mannitol, a frequently used excipient in the freeze drying industry. The results are subsequently used to study the effect that different freeze drying techniques have on the formation of these polymorphs. We find that, depending on the freeze-drying technique, the Mannitol either crystallizes in the delta form, or in a mixture of both the delta form and the beta form. The results are in agreement with conventional X-ray diffraction measurements used to identify the polymorphs.