𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease

✍ Scribed by Lars Timmermann; Lars Wojtecki; Joachim Gross; Ralph Lehrke; Jürgen Voges; Mohammed Maarouf; Harald Treuer; Volker Sturm; Alfons Schnitzler

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
285 KB
Volume
19
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation (≥130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD. © 2004 Movement Disorder Society

📜 SIMILAR VOLUMES

Postoperative gait deterioration after b
Postoperative gait deterioration after bilateral subthalamic nucleus stimulation in Parkinson's disease
✍ Bart F.L. van Nuenen; Rianne A.J. Esselink; Marten Munneke; Johhannes D. Speelma 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB

## Abstract Deep brain stimulation of the subthalamic nuclei (STN) is a good therapeutic option to reduce dyskinesias and improve appendicular motor signs in well‐selected patients with advanced Parkinson's disease (PD). Concerns about long‐term adverse effects play an increasingly role in the deci

Subthalamic nucleus stimulation selectiv
Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease
✍ Hélène Mollion; Peter Ford Dominey; Emmanuel Broussolle; Jocelyne Ventre-Dominey 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB 👁 1 views

## Abstract Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in s

Subthalamic nucleus stimulation restores
Subthalamic nucleus stimulation restores corticospinal facilitation in Parkinson's disease
✍ Monika Pötter-Nerger; Tihomir V. Ilic; Hartwiq R. Siebner; Günther Deuschl; Jens 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 115 KB

## Abstract We have previously shown that in patients with Parkinson's disease (PD), high‐frequency stimulation (HFS) of the subthalamic nucleus (STN) modifies spinal excitability via subcortical reticulospinal routes. To investigate whether STN‐HFS also modifies spinal excitability via transcortic

Postoperative management of subthalamic
Postoperative management of subthalamic nucleus stimulation for Parkinson's disease
✍ Paul Krack; Valérie Fraix; Alexandre Mendes; Alim-Louis Benabid; Pierre Pollak 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB

The postoperative neurologic management of patients with deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson' s disease is a complex dynamic process that involves a progressive increase in stimulation intensity and a parallel decrease in antiparkinsonian medication while asse

Subthalamic nucleus deep brain stimulati
Subthalamic nucleus deep brain stimulation improves deglutition in Parkinson's disease
✍ Michelle R. Ciucci; Julie M. Barkmeier-Kraemer; Scott J. Sherman 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB

## Abstract Relatively little is known about the role of the basal ganglia in human deglutition. Deep brain stimulation (DBS) affords us a model for examining deglutition in humans with known impairment of the basal ganglia. The purpose of this study was to examine the effects of subthalamic nuclei

Subthalamic nucleus stimulation affects
Subthalamic nucleus stimulation affects incentive salience attribution in Parkinson's disease
✍ Tereza Serranová; Robert Jech; Petr Dušek; Tomáš Sieger; Filip Růžička; Dušan Ur 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB

## Abstract Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can induce nonmotor side effects such as behavioral and mood disturbances or body weight gain in Parkinson's disease (PD) patients. We hypothesized that some of these problems could be related to an altered attribution of inc