𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Temporary complementation of temperature-sensitive mutants of the cell cycle by transfection with a wild-type or a mutant cDNA of ADP/ATP translocase

✍ Scribed by Hansjuerg Alder; Chung-Der Chang; Sing-Tsung Chen; Ingrid Beck; Chen-Yeh Chang; Renato Baserga

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
825 KB
Volume
141
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

A number of cell-cycle-specific temperature-sensitive (ts) mutants have been isolated from animal cells, especially Syrian hamster cells. These ts mutants, like cell cycle ts mutants of yeast, can be complemented by specific genes, some of which have been molecularly cloned. We have isolated a cDNA clone that complements TK-tsl3 cells, but only temporarily.

📜 SIMILAR VOLUMES

Restoration of wild-type conformation an
Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53V272M) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1
✍ Sophie North; Olivier Pluquet; Daniela Maurici; Fatiha El Ghissassi; Pierre Hain 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 199 KB

## Abstract The aminothiol WR1065, the active metabolite of the cytoprotector amifostine, exerts its antimutagenic effects through free‐radical scavenging and other unknown mechanisms. In an earlier report, we showed that WR1065 activates wild‐type p53 in MCF‐7 cells, leading to p53‐dependent arres