Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation

Increase in dopaminergic neurons from mo

Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-1α

✍ Tae-Sun Kim; Sachiyo Misumi; Cha-Gyun Jung; Tadashi Masuda; Yoshiaki Isobe; Fuji 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 387 KB

## Abstract A reliable method to induce neural progenitor/stem cells (NPCs) into dopaminergic (DAergic) neurons has not yet been established. As well, the mechanism involved remains to be elucidated. To induce DAergic differentiation from NPCs, a cytokine mixture (C‐Mix) of interleukin (IL)‐1β, IL‐