We have used Xenopus egg extracts to investigate the effects of the antitumor drug daunomycin on DNA replication in vitro. Xenopus sperm nuclei replicated nearly synchronously in our egg extracts, thereby allowing us to determine the effects of the drug on both replication initiation and elongation.
β¦ LIBER β¦
Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis
β Scribed by Gilbert, David M.; Dimitrova, Daniela S.
- Book ID
- 109771073
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 237 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1465-7392
- DOI
- 10.1038/35036309
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## Abstract Chromatin diminution is a precisely controlled, highly repeatable, genomeβwide deletion of noncoding heterochromatic segments from the presomatic line. The somatic line is reduced in size and reorganized; the germ line remains unaltered. Little is understood about its mechanistic underp