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Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex

✍ Scribed by Luisa Rocha; Sandra Orozco-Suarez; Mario Alonso-Vanegas; Juana Villeda-Hernandez; Andres Gaona; Eszter Páldy; Sandor Benyhe; Anna Borsodi

Book ID: 113812362
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 652 KB
Volume: 35
Category: Article
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2009.06.008

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## Abstract Mu opioid receptors (MOR) are known to be involved in seizure activity. The main goal of the present study was to characterize the MOR mRNA expression, binding, as well as G protein activation mediated by these receptors in epileptic hippocampus of patients with pharmacoresistant mesial