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Temporal induction of cytochrome p450 1a in the mirror carp (Cyprinus carpio) after administration of several polycyclic aromatic hydrocarbons

✍ Scribed by Martine E. J. Van Der Weiden; Frank H. M. Hanegraaf; Willem Seinen; Martin Van Den Berg; Martin L. Eggens; Malin Celander

Book ID: 112088612
Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 628 KB
Volume: 13
Category: Article
ISSN: 0730-7268
DOI: 10.1002/etc.5620130515

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a