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Temporal delineation of sequential HPRT mutations arising in vivo in a T-cell clone with a mutator phenotype

โœ Scribed by Vincent L. Wilson; Kerry R. Wade; Xiuqin Yin; Richard J. Albertini


Book ID
118539797
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
742 KB
Volume
473
Category
Article
ISSN
0027-5107

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Increases in peripheral blood T-lymphocyte HPRT mutant frequency may reflect either a number of independent HPRT gene mutational events or clonal proliferation of a single HPRT mutant. Sequence analysis of HPRT mutations in conjunction with Tcell receptor (TCR) gene rearrangement pattern analysis ca