Temporal cross-talk between TCR and STAT signals for CD8 T cell effector differentiation

Effector T-cell differentiation during v

Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8+ T cells

✍ Selina J. Keppler; Kerstin Theil; Smiljka Vucikuja; Peter Aichele 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 497 KB 👁 1 views

## Abstract To study the role of IL‐12 as a third signal for T‐cell activation and differentiation __in vivo__, direct IL‐12 signaling to CD8^+^ T cells was analyzed in bacterial and viral infections using the P14 T‐cell adoptive transfer model with CD8^+^ T cells that lack the IL‐12 receptor. Resu