Template-directed supramolecular assembly of a new type of nanoporous peptide-based material

✍ Scribed by Carl Henrik Görbitz; Frode Rise

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 804 KB
• Volume: 14
• Category: Article
• ISSN: 1075-2617
• DOI: 10.1002/psc.985

✦ Synopsis

Abstract

Dipeptides with two hydrophobic residues are known to often form crystals with hydrophobic or hydrophilic channels. One of the exceptions is Leu–Ile, which has been previously shown to crystallize as a nonporous 0.75 hydrate in the hexagonal space group __P__6~1~ with Z′ = 4. We have now found that in the presence of D‐Leu, a second pseudopolymorph of the dipeptide is formed. The crystal structure has hydrophilic, water‐filled channels with an irregular cross section of approximately 5.5 × 3.5 Å and constitutes the first example of a crystal packing arrangement where the direction of the channels is perpendicular to the direction of hydrophobic stacking of side chains rather than parallel as in all other porous peptide‐based materials. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.