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Template-directed CH activation: development and application to the total synthesis of 7-episordidin

✍ Scribed by Duncan J Wardrop; Raymond E Forslund; Chad L Landrie; Adriana I Velter; Donald Wink; Bushan Surve


Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
357 KB
Volume
14
Category
Article
ISSN
0957-4166

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✍ Jorma Hassfeld; Markus Kalesse 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 106 KB

The synthesis of a stereo pentade of the macrolide antibiotic oleandolide is reported. The C1 C7 fragment resembles the analogous segment of Panek's total synthesis of oleandolide. The use of the vinylogous Mukaiyama aldol reaction shortens the route significantly and has the advantage of utilizing