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Temperature-sensitive mutants of murine leukemia virus. V. Impaired leukemogenic activity in vivo

✍ Scribed by Joel S. Greenberger; John R. Stephenson; Stuart A. Aaronson

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
489 KB
Volume
15
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The in vivo biologic activities of a clonal isolate of the Rauscher strain of murine leukemia virus and several conditional lethal mutants with impaired replicative functions at the non‐permissive temperature were investigated. The parental virus induced a rapidly developing lymphoid leukemia in a high percentage of NIH Swiss mice inoculated as newborns. Mice inoculated in parallel with temperature‐sensitive mutant viruses showed no evidence of disease. The implications of these findings with regard to the requirements for type‐C virus replication to permit oncogenic transformation of lymphoid cells in vivo are discussed.

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