Temperature-Dependent Chemical Shift and Relaxation Times of 23Na in Na4HTm[DOTP]

✍ Scribed by Erik M Shapiro; Arijitt Borthakur; Navin Bansal; John S Leigh; Ravinder Reddy

• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 58 KB
• Volume: 143
• Category: Article
• ISSN: 1090-7807
• DOI: 10.1006/jmre.1999.2000

✦ Synopsis

We describe the characterization of a (23)Na temperature-dependent chemical shift and relaxation rates in the complex, Na(4)HTm[DOTP]. This is the first characterization of a (23)Na temperature-dependent chemical shift in a nonmetallic sample. The (23)Na temperature-dependent chemical shift coefficient is approximately -0. 5 PPM/ degrees C for both an aqueous solution and a 6% agarose gel of this compound. This is 50 times the magnitude of the temperature-dependent chemical shift coefficient of water protons. The relaxation times, T(1), T(2f), and T(2s) increased by 0.1, 0.01, and 0.05 ms/ degrees C, respectively. Applications of these unique properties for designing an MRI technique for monitoring heat deposition in tissue and tissue phantoms are discussed.