Temperature Dependence of Bimolecular Reactions Associated with Molecular Mobility in Lyophilized Formulations

Temperature- and glass transition temper

Temperature- and glass transition temperature-dependence of bimolecular reaction rates in lyophilized formulations described by the Adam-Gibbs-Vogel equation

✍ Sumie Yoshioka; Yukio Aso; Shigeo Kojima 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB

Bimolecular reaction rates in lyophilized aspirin-sulfadiazine formulations containing poly(vinylpyrrolidone), dextran, and isomalto-oligomers of different molecular weights were determined in the presence of various water contents, and their temperature-and glass transition temperature (T g )-depen