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Temperature-Controlled Regioselectivity in the Reductive Cleavage of p -Methoxybenzylidene Acetals

✍ Scribed by Hernández-Torres, Jesús M.; Achkar, Jihane; Wei, Alexander


Book ID
126062826
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
120 KB
Volume
69
Category
Article
ISSN
0022-3263

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A mild and ecient regioselective reductive opening of methoxybenzylidene acetals using a combination of Bu 3 SnH and MgBr 2 . OEt 2 , mainly via ®ve-membered chelation intermediates is described. This reaction was applied to synthetic intermediates of myriaporon and tedanolide.