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Temperature and pressure effects on conformational equilibria of alanine dipeptide in aqueous solution

✍ Scribed by Takahiro Takekiyo; Takashi Imai; Minoru Kato; Yoshihiro Taniguchi

Publisher: Wiley (John Wiley & Sons)
Year: 2004
Tongue: English
Weight: 183 KB
Volume: 73
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.10548

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✦ Synopsis

Abstract

We investigated the temperature and pressure effects on conformational equilibria of N‐acetyl‐L‐alanine‐N′‐methylamide (AAlaMA) in aqueous solution by Raman spectroscopy. Scattering intensities in the skeletal stretching mode of AAlaMA in aqueous solution were decomposed into some component bands by the spectra analysis. Our results indicate that each component band for AAlaMA adopts not only the P~II~ and α~R~ conformations but also the C~7eq~ conformation. From temperature and pressure dependencies of the band intensities, we determined the enthalpy differences and the volume differences between the conformers. The C~7eq~ conformer is enthalpically most stable due to the intramolecular hydrogen bond. The partial molar volume of the C~7eq~ conformer is the smallest through the solvent‐exclusion effect rather than the solute‐solvent electrostatic interaction effect. © 2004 Wiley Periodicals, Inc. Biopolymers 73: 283–290, 2004

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