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Temozolomide treatment for newly diagnosed anaplastic oligodendrogliomas: a clinical efficacy trial

✍ Scribed by A Taliansky-Aronov; F Bokstein; I Lavon; T Siegal


Book ID
106480431
Publisher
Springer US
Year
2006
Tongue
English
Weight
266 KB
Volume
79
Category
Article
ISSN
0167-594X

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## Abstract ## BACKGROUND Temozolomide (TMZ) and 1, 3‐bis (2‐chloroethyl)‐1‐nitrosourea (BCNU) are reported to be active agents in anaplastic glioma (AG). TMZ has also been shown to deplete alkyltransferase, a DNA repair enzyme that contributes to nitrosourea resistance. The objective of the curre