Telomeric Instability and Reduced Proliferative Potential in Ovarian Surface Epithelial Cells from Women with a Family History of Ovarian Cancer

Autonomy of the epithelial phenotype in

Autonomy of the epithelial phenotype in human ovarian surface epithelium: Changes with neoplastic progression and with a family history of ovarian cancer

✍ Helen G. Dyck; Thomas C. Hamilton; Andrew K. Godwin; Henry T. Lynch; Sarah Maine 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 949 KB

Epithelial ovarian carcinomas originate in the ovarian surface epithelium (OSE). In culture, OSE undergoes epithelio-mesenchymal conversion, an event mimicking a wound response, while ovarian carcinomas retain complex epithelial characteristics. To define the onset of this increased epithelial auton