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Telomeres and telomerase in paediatric patients with T-cell acute lymphoblastic leukaemia (T-ALL)

✍ Scribed by Kleideiter, E; Bangerter, U; Schwab, M; Boukamp, P; Koscielniak, E; Klotz, U; Greil, J

Book ID: 110056119
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 121 KB
Volume: 19
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2403596

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## BACKGROUND. Telomeres shorten with successive cell divisions in normal somatic cells. Telomerase is a ribonucleoprotein enzyme associated with cellular proliferation and plays an important role in maintaining the stability of chromosomes and the length of DNA telomeres. Telomerase activity has