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Telomere shortening with aging in human esophageal mucosa

โœ Scribed by Kaiyo Takubo; Ken-Ichi Nakamura; Naotaka Izumiyama; Motoji Sawabe; Tomio Arai; Yukiyoshi Esaki; Yoichi Tanaka; Ken-Ichi Mafune; Mutsunori Fujiwara; Makoto Kammori; Koji Sasajima


Publisher
Springer Netherlands
Year
1999
Tongue
English
Weight
641 KB
Volume
22
Category
Article
ISSN
0161-9152

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Chromosomal instability (CIN) leads to an increase in aneuploidy and chromosomal aberrations in human hepatocellular carcinoma (HCC). Telomere shortening appears as one mechanism fostering the development of CIN. Whether telomere shortening correlates to specific genetic changes that characterize a