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Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

✍ Scribed by Utz Herbig; Wendy A Jobling; Benjamin P.C Chen; David J Chen; John M Sedivy

Book ID
117737425
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
801 KB
Volume
14
Category
Article
ISSN
1097-2765

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✍ Masahiko Obata; Emi Imamura; Yukinori Yoshida; Junichi Goto; Kan Kishibe; Atsumi πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 241 KB

Primary cultured mouse hepatic cells become senescent within a short period, although rare cells form colonies from which continuously proliferating cell lines can be established. In contrast, hepatic tumor (HT) cells show little senescence and higher colony-forming capacity. To assess this differen