Stochastic Mechanism of Cellular AgingβA
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Ivica Rubelj; Zoran Vondracek
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Article
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1999
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Elsevier Science
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English
β 190 KB
A strong stochastic component has been described for the appearance of senescent cells in cultures that have not completed their in vitro lifespan. The proliferative potential of individual clones show a bimodal distribution. Additionally, two cells arising from a single mitotic event can exhibit la