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Telomere Lengths and Telomerase Activity in Dog Tissues: A Potential Model System to Study Human Telomere and Telomerase Biology

โœ Scribed by Nasir, Lubna; Devlin, Pauline; Mckevitt, Tom; Rutteman, Gerard; Argyle, David J.

Book ID
125435023
Publisher
Neoplasia Press
Year
2001
Tongue
English
Weight
312 KB
Volume
3
Category
Article
ISSN
1522-8002

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A novel platinum compound inhibits telom
A novel platinum compound inhibits telomerase activity in vitro and reduces telomere length in a human hepatoma cell line
โœ Miho Furuta; Katsura Nozawa; Masaharu Takemura; Shunji Izuta; Takashi Murate; Ma ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 275 KB

## Abstract Telomerase activity is detectable in most human tumors but not in most normal somatic cells or tissues. Telomerase inhibition has, therefore, been proposed as a novel and potentially selective strategy for antitumor therapy. In the present study, we found that platinum compounds, includ