Telomerase reverse transcriptase and telomeric-repeat binding factor protein 1 as regulators of telomerase activity in pancreatic cancer cells
โ Scribed by Yajima, T; Yagihashi, A; Kameshima, H; Kobayashi, D; Hirata, K; Watanabe, N
- Book ID
- 111724590
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 88 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0007-0920
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## Abstract ## BACKGROUND Telomere maintenance has been proposed as an essential step for tumor cell immortalization. The objectives of the current study were to investigate the mechanisms implicated in telomere length in colorectal carcinoma (CRC) and to evaluate the prognostic impact of telomere
Telomerase activity is suppressed in normal human somatic tissues but is activated in cancer cells and immortal cell lines. The reverse transcriptase (RT) subunit human telomerase reverse transcriptase (hTERT) is the key regulator of telomerase activity. The hTERT promoter contains E-box elements an