Telomerase regulation and progressive telomere shortening of rat hepatic stem-like epithelial cells during in vitro aging

Telomere shortening, telomerase expressi

Telomere shortening, telomerase expression, and chromosome instability in rat hepatic epithelial stem-like cells

✍ Vita M. Golubovskaya; Leonid V. Filatov; Cynthia I. Behe; Sharon C. Presnell; Mi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 949 KB

Telomeres, which are specialized structures consisting of T 2 AG 3 repeats and proteins at the ends of chromosomes, may be essential for genomic stability. To test whether telomere length maintenance preserves genomic stability in rats (Rattus rattus and Fischer 344), we assayed telomerase activity