Telomerase RNA component (TERC) and telomerase reverse transcriptase (TERT) function together to elongate telomeres and to protect chromosomal ends. Recent studies have discovered that overexpression of telomerase's TERT subunit promoted epidermal stem-cell mobilization, hair growth and stem-cell pr
Telomerase-independent mechanisms of telomere elongation
β Scribed by H. Biessmann; J.M. Mason
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 256 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1420-682X
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## Abstract Telomerase is a ribonucleoprotein complex critically involved in extending and maintaining telomeres. Unlike the majority of somatic cells, in which hTERT and telomerase activity are generally silent, normal lymphocytes show transient physiological hTERT expression and telomerase activi
Introduction of telomerase into normal cells provides telomere maintenance and an extended cellular life span, establishing the critical role of telomere attrition in cellular senescence. Additional data surrounding this observation suggest that expression of telomerase renders these "mortal" cells