Telomerase as a therapeutic target for Barrett's-associated esophageal adenocarcinoma
β Scribed by Koley, Hemanta; Shammas, Masood; Munshi, Nikhil; Beer, David G.; Goyal, Raj
- Book ID
- 122552887
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 255 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Given the poor survival rate and efficacy of current therapy for esophageal adenocarcinoma (EAC), there is a need to identify and develop new therapeutic targets for treatment. Microarray analysis (Affymetrix U133A GeneChips, Robust MultiβChip Analysis) was used to expression profile 11
## BACKGROUND. The rate of incidence of esophageal adenocarcinoma has surpassed that of all other malignancies in the U.S. Esophageal adenocarcinoma arises from Barrett's esophagus through the multistep accumulation of genetic mutations in metaplastic cells, accompanied by histologic changes from