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Telomerase activity (TA) in breast cancer and its correlation with other biological and pathological parameters

✍ Scribed by A. Lucenti; P. Slomp; R. Togni; M. Barbareschi; S. Girlando; O. Caffo; A. Ferro; S. Brugnara; F. Valduga; E. Galligioni

Book ID
117658852
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
359 KB
Volume
37
Category
Article
ISSN
0959-8049

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Cell cycle deregulation can occur at different levels in cancer. In human breast cancer it includes overexpression of cyclins D1 and E, down-regulation of cyclin-dependent kinase inhibitors and inactivation of the retinoblastoma and p53 tumor suppressor proteins. Telomerase activity is strongly asso