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Telomerase activity is widespread in adult somatic tissues ofXenopus

✍ Scribed by Bousman, Sylvia ;Schneider, Gerard ;Shampay, Janis

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
194 KB
Volume
295B
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

Chromosome ends, or telomeres, are maintained by telomerase. Work in selected vertebrates has implied that telomerase is often repressed in differentiated cells, and telomere erosion results in senescence of cultured cells. Tissues from mature Xenopus laevis frogs were examined for telomerase enzymatic activity with the TRAP (telomere repeat amplification protocol) assay. All tissues contained active telomerase, most abundantly in testis, spleen, liver, and embryos; activity was less abundant but still readily detectable with < 100 ng of protein extract from brain and muscle tissues. Activity in somatic tissues of the diploid Xenopus tropicalis suggests this condition is not limited to the polyploid members of the genus, and that extensive differentiation‐linked telomerase repression does not occur in Xenopus. J. Exp. Zool. (Mol. Dev. Evol.) 295B:82–86, 2003. © 2003 Wiley‐Liss, Inc.

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