## Abstract The aim of our study was to prospectively evaluate the potential diagnostic value and clinical applicability of quantitative analysis of telomerase subunits gene expression in urine for noninvasive detection of bladder cancer. Expression levels of human telomerase reverse transcriptase
Telomerase activity in urine sediments as a tool for noninvasive detection of bladder cancer
โ Scribed by A. Dettlaff-Pokora; M. Matuszewski; B. Schlichtholz
- Book ID
- 116333351
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 97 KB
- Volume
- 222
- Category
- Article
- ISSN
- 0304-3835
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## Background: Telomerase is an enzyme that can reconstitute the ends (telomeres) of chromosomes after cell division and thus circumvent the cumulative damage that occurs in normal adult somatic cells during successive mitotic cycles. recently, it has been proposed that this enzyme should, therefor
## METHODS. The authors used a polymerase chain reaction (PCR)-based telomeric repeat amplification protocol (TRAP) assay to determine the presence of te-Department of Urology, Mount Sinai School of lomerase activity in voided urine samples from patients with known but yet un-Medicine, New York, N