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Telomerase activity in solid transitional cell carcinoma, bladder washings, and voided urine

✍ Scribed by Raymond S. Lance; Wade K. Aldous; Jason Blaser; J.Brantley Thrasher


Book ID
117724756
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
559 KB
Volume
4
Category
Article
ISSN
1078-1439

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## METHODS. The authors used a polymerase chain reaction (PCR)-based telomeric repeat amplification protocol (TRAP) assay to determine the presence of te-Department of Urology, Mount Sinai School of lomerase activity in voided urine samples from patients with known but yet un-Medicine, New York, N

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## Background: Telomerase activity is not detectable in normal cells, and their telomers shorten until the chromosome is unable to replicate. immortal cells have short but stable chromosomes and increased telomerase activity. transitional cell carcinoma (tcc) has only a few useful markers of diagno