## Abstract ## BACKGROUND Significantly elevated telomerase activity (TA) has been found in samples from patients with many malignant hematologic diseases. However, the impact of elevated TA on the course of patients with chronic phase chronic myeloid leukemia (CPβCML) is unknown. ## METHODS Usi
Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression
β Scribed by Ohyashiki, K; Ohyashiki, J H; Iwama, H; Hayashi, S; Shay, J W; Toyama, K
- Book ID
- 110053418
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 73 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0887-6924
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Telomeres are specialized structures localized at the end of human chromosomes. Due to the end replication problem, each cell division results in a loss of telomeric repeats in normal somatic cells. In germ line and stem cells, the multicomponent enzyme telomerase maintains the length o
## Abstract ## BACKGROUND Significantly elevated telomerase activity (TA) has been found in samples from patients with almost all malignant hematologic diseases. The impact of elevated TA on the course of pediatric patients with acute myeloid leukemia (PβAML) is unknown. ## METHODS Using a modif
We evaluated the association of circulating levels of heat shock protein 70 (Hsp70) in plasma with clinical behavior and progression in 139 chronic myeloid leukemia (CML) patients. Circulating Hsp70 levels did not differ significantly between CML patients in the chronic phase (n=93; median 33.24 ng/