Telomerase activity has been detected in germ cells as well as in the developing embryo. Activity is no longer detectable in most somatic cells of the neonate, although low levels of activity persist in regenerative tissues. Telomerase has been found to be reactivated or up-regulated in the majority
Telomerase Activation inin Vitroandin VivoCervical Carcinogenesis
β Scribed by Peng-Sheng Zheng; Tsuyoshi Iwasaka; Masatoshi Yokoyama; Yoshifumi Nakao; Alan Pater; Hajime Sugimori
- Book ID
- 112247157
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 550 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0090-8258
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The human telomerase enzyme is composed of two essential components, hTR, which acts as a template for reverse transcription, and hTERT, which is the putative catalytic subunit for the enzyme. Recent studies have demonstrated a good correlation between hTERT expression and telomerase activation, whe
Telomerase is a ribonucleoprotein complex intimately involved in cell immortalization and carcinogenesis. This enzyme is activated and stabilizes telomere length in almost all types of cancer. Telomerase may be necessary for continuous cell proliferation. In this study, we analyzed telomerase activi