Telomerase activation and cancer
โ Scribed by Aloysius J. Klingelhutz
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 192 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0946-2716
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## Background: The purpose of the current study was to determine telomerase activity as a sensitive biomarker for the detection of malignant cells in fine-needle aspiration (fna) specimens. ## Methods: Fna specimens with parallel samples of fresh tumor tissue were obtained from surgical specimens
Telomerase activity has been detected in germ cells as well as in the developing embryo. Activity is no longer detectable in most somatic cells of the neonate, although low levels of activity persist in regenerative tissues. Telomerase has been found to be reactivated or up-regulated in the majority
Telomerase activity has been examined extensively in a variety of human cancerous and noncancerous tissues. However, it was sometimes difficult to measure telomerase activity quantitatively with the methods used and in the tissues examined. We examined telomerase activity quantitatively in gastroint