Tellurium-Based Polymeric Surfactants as a Novel Seleno-Enzyme Model with High Activity

✍ Scribed by Xin Huang; Zeyuan Dong; Junqiu Liu; Shizhong Mao; Guimin Luo; Jiacong Shen

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 147 KB
• Volume: 27
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.200600468

✦ Synopsis

Abstract

Summary: A tellurium‐based polymeric sufactant as a seleno‐enzyme model has been constructed by employing 11‐acryloyloxyundecyltriethylammonium bromide (AUTEAB, 4) and a tellurium‐containing compound (1). It demonstrates strong substrate binding ability for thiols and high glutathione peroxidase (GPx) activity about 6 orders of magnitude more efficient than the well‐known GPx mimic PhSeSePh in an ArSH assay system. More importantly, a series of tellurium‐based polymeric micelle catalysts with the catalytic tellurium center located at various positions in the micelle have been constructed, and the dramatic difference in activity indicates that the exact match of the catalytic center and binding site plays a key role in enzyme catalytic efficiency.

Schematic representation of the proposed mode of the telluro‐micelle catalysts.

magnified imageSchematic representation of the proposed mode of the telluro‐micelle catalysts.