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Tele vs. Oxidative Substitution of Hydrogen in meta Monochloromethyl, Dichloromethyl, and Trichloromethyl Nitrobenzenes in the Reaction with Grignard Reagents

✍ Scribed by Mieczysław Mąkosza; George Varvounis; Marek Surowiec; Thomas Giannopoulo


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
137 KB
Volume
2003
Category
Article
ISSN
1434-193X

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✦ Synopsis


Abstract

Grignard reagents add to nitrobenzene derivatives containing trichloromethyl, dichloromethyl, and monochloromethyl groups in the meta position to form σ^H^ adducts, which are either further converted through departure of a chloride anion, giving products of tele substitution, or oxidized to products of oxidative nucleophilic substitution of hydrogen. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)